Remdesivir in combination with dexamethasone for patients hospitalized with COVID-19: A retrospective multicenter study.

ABSTRACT:

Background

Dexamethasone is standard of care for the treatment of patients with COVID-19 requiring oxygen. The objective is to assess the clinical benefit of adding remdesivir to dexamethasone.

Patients and methods

A retrospective cohort study of hospitalized patients with COVID-19 pneumonia requesting low-flow oxygen who received dexamethasone. Patients admitted to infectious diseases wards also received remdesivir. Primary outcome was duration of hospitalization after oxygen initiation. Secondary outcomes were in-hospital death, and death and/or transfer to the intensive care unit. To handle potential confounding by indication bias, outcome comparison was performed on propensity score-matched populations. Propensity score was estimated by a multivariable logistic model inc

SUBMITTER: Gressens SB 

PROVIDER: S-EPMC8853490 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature