Strategies for meiotic sex chromosome dynamics and telomeric elongation in Marsupials.

ABSTRACT: During meiotic prophase I, homologous chromosomes pair, synapse and recombine in a tightly regulated process that ensures the generation of genetically variable haploid gametes. Although the mechanisms underlying meiotic cell division have been well studied in model species, our understanding of the dynamics of meiotic prophase I in non-traditional model mammals remains in its infancy. Here, we reveal key meiotic features in previously uncharacterised marsupial species (the tammar wallaby and the fat-tailed dunnart), plus the fat-tailed mouse opossum, with a focus on sex chromosome pairing strategies, recombination and meiotic telomere homeostasis. We uncovered differences between phylogroups with important functional and evolutionary implications. First, sex chromosomes, which lack a pseu

SUBMITTER: Marin-Gual L 

PROVIDER: S-EPMC8853506 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature