INTEGRATE: Model-based multi-omics data integration to characterize multi-level metabolic regulation.

ABSTRACT: Metabolism is directly and indirectly fine-tuned by a complex web of interacting regulatory mechanisms that fall into two major classes. On the one hand, the expression level of the catalyzing enzyme sets the maximal theoretical flux level (i.e., the net rate of the reaction) for each enzyme-controlled reaction. On the other hand, metabolic regulation controls the metabolic flux through the interactions of metabolites (substrates, cofactors, allosteric modulators) with the responsible enzyme. High-throughput data, such as metabolomics and transcriptomics data, if analyzed separately, do not accurately characterize the hierarchical regulation of metabolism outlined above. They must be integrated to disassemble the interdependence between different regulatory layers controlling metabolism. T

SUBMITTER: Di Filippo M 

PROVIDER: S-EPMC8853556 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature