Ontology highlight
ABSTRACT:
SUBMITTER: Mendoza A
PROVIDER: S-EPMC8853622 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Mendoza Arturo A Tang Catherine C Choi Jinyoung J Acuña Mariana M Logan Maya M Martin Adriana G AG Al-Sowaimel Lujain L Desai Bhavna N BN Tenen Danielle E DE Jacobs Christopher C Lyubetskaya Anna A Fu Yulong Y Liu Hong H Tsai Linus L Cohen David E DE Forrest Douglas D Wilson Andrew A AA Hollenberg Anthony N AN
Science signaling 20211116 709
Thyroid hormone (TH) action is essential for hepatic lipid synthesis and oxidation. Analysis of hepatocyte-specific thyroid receptor β1 (TRβ1) knockout mice confirmed a role for TH in stimulating de novo lipogenesis and fatty acid oxidation through its nuclear receptor. Specifically, TRβ1 and its principal corepressor NCoR1 in hepatocytes repressed de novo lipogenesis, whereas the TH-mediated induction of lipogenic genes depended on the transcription factor ChREBP. Mice with a hepatocyte-specifi ...[more]