Elevated magnetic resonance imaging measures of adipose tissue deposition in women with breast cancer treatment-related lymphedema.

ABSTRACT:

Purpose

Breast cancer treatment-related lymphedema (BCRL) is a common co-morbidity of breast cancer therapies, yet factors that contribute to BCRL progression remain incompletely characterized. We investigated whether magnetic resonance imaging (MRI) measures of subcutaneous adipose tissue were uniquely elevated in women with BCRL.

Methods

MRI at 3.0 T of upper extremity and torso anatomy, fat and muscle tissue composition, and T₂ relaxometry were applied in left and right axillae of healthy control (n = 24) and symptomatic BCRL (n = 22) participants to test the primary hypothesis that fat-to-muscle volume fraction is elevated in symptomatic BCRL relative to healthy participants, and the secondary hypothesis that fat-to-muscle volume fraction is correlated with MR

SUBMITTER: Crescenzi R 

PROVIDER: S-EPMC8853636 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature