Coupling of pupil- and neuronal population dynamics reveals diverse influences of arousal on cortical processing.

ABSTRACT: Fluctuations in arousal, controlled by subcortical neuromodulatory systems, continuously shape cortical state, with profound consequences for information processing. Yet, how arousal signals influence cortical population activity in detail has so far only been characterized for a few selected brain regions. Traditional accounts conceptualize arousal as a homogeneous modulator of neural population activity across the cerebral cortex. Recent insights, however, point to a higher specificity of arousal effects on different components of neural activity and across cortical regions. Here, we provide a comprehensive account of the relationships between fluctuations in arousal and neuronal population activity across the human brain. Exploiting the established link between pupil size and central ar

SUBMITTER: Pfeffer T 

PROVIDER: S-EPMC8853659 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature