Metabolic correlates of late midlife cognitive outcomes: findings from the 1946 British Birth Cohort.

ABSTRACT: Investigating associations between metabolites and late midlife cognitive function could reveal potential markers and mechanisms relevant to early dementia. Here, we systematically explored the metabolic correlates of cognitive outcomes measured across the seventh decade of life, while untangling influencing life course factors. Using levels of 1019 metabolites profiled by liquid chromatography-mass spectrometry (age 60-64), we evaluated relationships between metabolites and cognitive outcomes in the British 1946 Birth Cohort (N = 1740). We additionally conducted pathway and network analyses to allow for greater insight into potential mechanisms, and sequentially adjusted for life course factors across four models, including sex and blood collection (Model 1), Model 1 + body mass in

SUBMITTER: Green R 

PROVIDER: S-EPMC8853724 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature