Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds.

ABSTRACT:

Purpose

To investigate potential interactions between dietary patterns and genetic factors modulating risk for Alzheimer's disease (AD) in relation to incident dementia.

Methods

Data were derived from the population-based Gothenburg H70 Birth Cohort Studies in Sweden, including 602 dementia-free 70-year-olds (examined 1992-93, or 2000-02; 64% women) followed for incident dementia until 2016. Two factors from a reduced rank regression analysis were translated into dietary patterns, one healthy (e.g., vegetables, fruit, and fish) and one western (e.g., red meat, refined cereals, and full-fat dairy products). Genetic risk was determined by APOE ε4 status and non-APOE AD-polygenic risk scores (AD-PRSs). Gene-diet interactions in relation to incident dementia were analysed with C

SUBMITTER: Samuelsson J 

PROVIDER: S-EPMC8854136 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature