The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells.

ABSTRACT:

Background

A major feature of the microenvironment in pancreatic ductal adenocarcinoma (PDAC) is the significant amount of extracellular matrix produced by pancreatic stellate cells (PSCs), which have been reported to enhance the invasiveness of pancreatic cancer cells and negatively impact the prognosis.

Methods

We analyzed the data from two publicly available microarray datasets deposited in the Gene Expression Omnibus and found candidate genes that were differentially expressed in PDAC cells with metastatic potential and PDAC cells cocultured with PSCs. We studied the interaction between PDAC cells and PSCs in vitro and verified our finding with the survival data of patients with PDAC from the website of The Human Protein Atlas.

Results

We found that PSCs stimulate

SUBMITTER: Kung PJ 

PROVIDER: S-EPMC8854169 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature