TRmir: A Comprehensive Resource for Human Transcriptional Regulatory Information of MiRNAs.

ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNAs, which play important roles in regulating various biological functions. Many available miRNA databases have provided a large number of valuable resources for miRNA investigation. However, not all existing databases provide comprehensive information regarding the transcriptional regulatory regions of miRNAs, especially typical enhancer, super-enhancer (SE), and chromatin accessibility regions. An increasing number of studies have shown that the transcriptional regulatory regions of miRNAs, as well as related single-nucleotide polymorphisms (SNPs) and transcription factors (TFs) have a strong influence on human diseases and biological processes. Here, we developed a comprehensive database for the human transcriptional regulation of miRNAs (TRmir),

SUBMITTER: Gao Y 

PROVIDER: S-EPMC8854293 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature