Elevated expression of B7 homolog 4 is associated with disease progression in upper urinary tract urothelial carcinoma.

ABSTRACT:

Background

B7 homolog 4 (B7-H4) is a negative regulator of immune responses, but its immunoregulatory role in the tumor microenvironment of upper urinary tract urothelial carcinoma (UTUC) remains unclear.

Methods

We measured the immunohistochemical expression of B7-H4, CD8 and T cell intracellular antigen 1 (TIA-1), a marker of activated CD8, in 133 patients with UTUC who underwent nephroureterectomy. We also studied the relationship between B7-H4, CD8 and TIA-1 expression and clinicopathological characteristics.

Results

B7-H4 was mainly expressed on the surface in tumor cells, while CD8 and TIA-1 were often expressed in tumor-infiltrating lymphocytes. Elevated expression of B7-H4 in tumor cells was associated with a poorer histological grade, higher pT stage, regiona

SUBMITTER: Mizuno T 

PROVIDER: S-EPMC8854319 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature