Dynamic network impairments underlie cognitive fluctuations in Lewy body dementia.

ABSTRACT: Cognitive fluctuations are a characteristic and distressing disturbance of attention and consciousness seen in patients with Dementia with Lewy bodies and Parkinson's disease dementia. It has been proposed that fluctuations result from disruption of key neuromodulatory systems supporting states of attention and wakefulness which are normally characterised by temporally variable and highly integrated functional network architectures. In this study, patients with DLB (n = 25) and age-matched controls (n = 49) were assessed using dynamic resting state fMRI. A dynamic network signature of reduced temporal variability and integration was identified in DLB patients compared to controls. Reduced temporal variability correlated significantly with fluctuation-related measures using a sustained atte

SUBMITTER: Matar E 

PROVIDER: S-EPMC8854384 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature