Neoadjuvant therapy alters the collagen architecture of pancreatic cancer tissue via Ephrin-A5.

ABSTRACT:

Background

The treatment of pancreatic cancer (PDAC) remains clinically challenging, and neoadjuvant therapy (NAT) offers down staging and improved surgical resectability. Abundant fibrous stroma is involved in malignant characteristic of PDAC. We aimed to investigate tissue remodelling, particularly the alteration of the collagen architecture of the PDAC microenvironment by NAT.

Methods

We analysed the alteration of collagen and gene expression profiles in PDAC tissues after NAT. Additionally, we examined the biological role of Ephrin-A5 using primary cultured cancer-associated fibroblasts (CAFs).

Results

The expression of type I, III, IV, and V collagen was reduced in PDAC tissues after effective NAT. The bioinformatics approach provided comprehensive insights into

SUBMITTER: Nakajima K 

PROVIDER: S-EPMC8854423 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature