Human-Induced CD49a⁺ NK Cells Promote Fetal Growth.

ABSTRACT: CD49a⁺ natural killer (NK) cells play a critical role in promoting fetal development and maintaining immune tolerance at the maternal-fetal interface during the early stages of pregnancy. However, given their residency in human tissue, thorough studies and clinical applications are difficult to perform. It is still unclear as to how functional human CD49a⁺ NK cells can be induced to benefit pregnancy outcomes. In this study, we established three no-feeder cell induction systems to induce human CD49a⁺ NK cells from umbilical cord blood hematopoietic stem cells (HSCs), bone marrow HSCs, and peripheral blood NK cells in vitro. These induced NK cells (iNKs) from three cell induction systems display high levels of CD49a, CD9, CD39, CD151 expression, low l

SUBMITTER: Du X 

PROVIDER: S-EPMC8854499 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature