Ontology highlight
ABSTRACT:
SUBMITTER: Zeng W
PROVIDER: S-EPMC8854658 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Zeng Wenshu W Yue Lu L Lam Kim S W KSW Zhang Wenxin W So Wai-Kin WK Tse Erin H Y EHY Cheung Tom H TH
Nature communications 20220217 1
Skeletal muscle stem cells, also called Satellite Cells (SCs), are actively maintained in quiescence but can activate quickly upon extrinsic stimuli. However, the mechanisms of how quiescent SCs (QSCs) activate swiftly remain elusive. Here, using a whole mouse perfusion fixation approach to obtain bona fide QSCs, we identify massive proteomic changes during the quiescence-to-activation transition in pathways such as chromatin maintenance, metabolism, transcription, and translation. Discordant co ...[more]