The Role of Carbon Dioxide in the Rat Acute Stroke Penumbra.

ABSTRACT:

Purpose

The vasodilatory response to inhaled CO₂ occurs in the acute stroke ischemic penumbra and may be a potential therapeutic modality.

Methods

Twenty-two Sprague-Dawley rats were subjected to 90-min occlusion of the M2 segment of the middle cerebral artery (M2CAO) by endovascular technique. The animals were administered different C02 concentrations and scanned serially with 9.4 T MRI. Infarct tissue was determined by diffusion-weighted imaging (DWI) and hypoperfused tissue was determined by arterial spin labeling (PWI).

Results

4 animals were administered room air (RA)+ 6% CO₂ (group 1), 6 animals RA+12% CO₂ (Group 2) and 4 animals only RA (group 3). In the rats with CO₂ administered (groups 1 and 2), the DWI lesion to c

SUBMITTER: Yeo LL 

PROVIDER: S-EPMC8854855 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature