CCR2⁺ Macrophages Promote Orthodontic Tooth Movement and Alveolar Bone Remodeling.

ABSTRACT: During mechanical force-induced alveolar bone remodeling, macrophage-mediated local inflammation plays a critical role. Yet, the detailed heterogeneity of macrophages is still unknown. Single-cell RNA sequencing was used to study the transcriptome heterogeneity of macrophages during alveolar bone remodeling. We identified macrophage subclusters with specific gene expression profiles and functions. CellChat and trajectory analysis revealed a central role of the Ccr2 cluster during development, with the CCL signaling pathway playing a crucial role. We further demonstrated that the Ccr2 cluster modulated bone remodeling associated inflammation through an NF-κB dependent pathway. Blocking CCR2 could significantly reduce the Orthodontic tooth movement (OTM) progression. In additio

SUBMITTER: Xu H 

PROVIDER: S-EPMC8854866 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature