Single Cell RNA Sequencing Reveals Critical Functions of Mkx in Periodontal Ligament Homeostasis.

ABSTRACT: The periodontal ligament (PDL) comprises a fibrous tissue that connects teeth to alveolar bone and is essential for periodontal function. The transcription factor mohawk homeobox (Mkx) is expressed in the PDL where it plays an important role in the development and maintenance of the PDL. However, the precise and critical functions of Mkx in the cell populations comprising PDL have not yet been elucidated. The present study aimed to clarify the effects of a Mkx deficiency on PDL cellular heterogeneity and differences between gene expression in PDL tissues from wild-type (WT) (Mkx ^+/+ ) and Mkx knockout (Mkx ^-/- ) rats using single-cell RNA sequencing. We identified 12 cell clusters comprising mesenchymal cells and

SUBMITTER: Takada K 

PROVIDER: S-EPMC8854991 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature