Applicability of Transcatheter Aortic Valve Replacement Trials to Real-World Clinical Practice: Findings From EXTEND-CoreValve.

ABSTRACT:

Objectives

The aim of this study was to examine the applicability of pivotal transcatheter aortic valve replacement (TAVR) trials to the real-world population of Medicare patients undergoing TAVR.

Background

It is unclear whether randomized controlled trial results of novel cardiovascular devices apply to patients encountered in clinical practice.

Methods

Characteristics of patients enrolled in the U.S. CoreValve pivotal trials were compared with those of the population of Medicare beneficiaries who underwent TAVR in U.S. clinical practice between November 2, 2011, and December 31, 2017. Inverse probability weighting was used to reweight the trial cohort on the basis of Medicare patient characteristics, and a "real-world" treatment effect was estimated.

Results

SUBMITTER: Butala NM 

PROVIDER: S-EPMC8855223 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature