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A Perspective on Late-Stage Aromatic C-H Bond Functionalization.

ABSTRACT: Late-stage functionalization of C-H bonds (C-H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules. However, C-H LSF is challenging because the C-H bond must be functionalized in the presence of various other functional groups. In this Perspective, we evaluate aromatic C-H LSF on the basis of four criteria─reactivity, chemoselectivity, site-selectivity, and substrate scope─and provide our own views on current challenges as well as promising strategies and areas of growth going forward.

SUBMITTER: Zhang L

PROVIDER: S-EPMC8855345 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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A Perspective on Late-Stage Aromatic C-H Bond Functionalization.

Zhang Li L Ritter Tobias T

Journal of the American Chemical Society 20220127 6

Late-stage functionalization of C-H bonds (C-H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules. However, C-H LSF is challenging because the C-H bond must be functionalized in the presence of various other functional groups. In this Perspective, we evaluate aromatic C-H LSF on the basis of four criteria─reactivity, chemoselectivity, site-selectivity, and substrate scope─and provide our own views on current challenges as well as promising ...[more]

PMID: 35084173

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