Patterned Dried Blood Spot Cards for the Improved Sampling of Whole Blood.

ABSTRACT: Dried blood spot (DBS) cards perform many functions for sampling blood that is intended for subsequent laboratory analysis, which include: (i) obviating the need for a phlebotomist by using fingersticks, (ii) enhancing the stability of analytes at ambient or elevated environmental conditions, and (iii) simplifying the transportation of samples without a cold chain. However, a significant drawback of standard DBS cards is the potential for sampling bias due to unrestricted filling caused by the hematocrit of blood, which often limits quantitative or reproducible measurements. Alternative microsampling technologies have minimized or eliminated this bias by restricting blood distribution, but these approaches deviate from clinical protocols and present a barrier to broad adoption. Herein, we

SUBMITTER: Baillargeon KR 

PROVIDER: S-EPMC8855418 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature