Durable outcomes of double cord blood transplantation in adults with acute lymphoblastic leukemia: high-risk features for early and long-term mortality.

ABSTRACT:

Background

Cord blood transplantation (CBT) has been reported as an acceptable option with comparable outcomes to conventional donors in adults with acute lymphoblastic leukemia (ALL). We aimed to analyze the long-term CBT outcomes and risk factors for early and long-term mortalities.

Methods

Between 2006 and 2020, 112 patients (median age: 35 years; 62 Ph-negative ALL and 50 Ph-positive ALL) were treated with double CBT. Conditioning regimen consisted of total body irradiation (12 Gy) plus cytarabine (9.0 g/m²) plus fludarabine (150 mg/ m²), and graft-versus-host disease (GVHD) prophylaxis was attempted by administering tacrolimus plus mycophenolate mofetil.

Results

The median time for neutrophil and platelet recovery was 25 days (range: 5-59 da

SUBMITTER: Yoon JH 

PROVIDER: S-EPMC8855448 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature