Two-year immune effect differences between the 0-1-2-month and 0-1-6-month HBV vaccination schedule in adults.

ABSTRACT:

Background

The short-term 0-1-2-month hepatitis B virus (HBV) vaccination schedule was previously implemented in the adult population; however, its long-term immune effect remains unclear. The present study aimed to investigate (1) the 2-month and 2-year immune effects of HBV vaccination and (2) the compliance rate between the 0-1-2-month and 0-1-6-month vaccination schedules in adults.

Method

A total of 1281 subjects tested for hepatitis B surface antigen HBsAg(-) and hepatitis B surface antibody (anti-HBs)(-) were recruited. Participants from two distant counties were inoculated with the hepatitis B yeast vaccine at 10 µg per dose, with vaccination schedules of 0, 1, and 2 months (n = 606) and 0, 1, and 6 months (n = 675); sequential follow-up was performed at 2 months and

SUBMITTER: Wang J 

PROVIDER: S-EPMC8855546 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature