Gastrodin promotes the regeneration of peripheral nerves by regulating miR-497/BDNF axis.

ABSTRACT:

Background

Gastrodin (GAS), is a kind of phenolic compound extracted from the traditional Chinese herbal medicine Gastrodia elata Blume (GEB). This study was aimed at probing into the protective effect of GAS on peripheral nerve injury (PNI) and the underlying mechanism.

Methods

A rat model with PNI was established, followed by intraperitoneal injection of GAS (20 mg/kg/day). Sciatic nerve function index (SFI) was used to analyze the function of sciatic nerve. The amplitude and latency of compound muscle action potential (CMAP) were examined by electrophysiology. Schwann cells (SCs) were isolated from fetal rats and treated with GAS 200 μg/mL, and H₂O₂-induced model of oxidative stress injury was established. EdU and Transwell assays were adopted to det

SUBMITTER: Yongguang L 

PROVIDER: S-EPMC8855574 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature