NCAPG promotes the oncogenesis and progression of non-small cell lung cancer cells through upregulating LGALS1 expression.

ABSTRACT:

Background

Numerous common oncogenic driver events have been confirmed in non-small cell lung cancer (NSCLC). Although targeted therapy has revolutionized NSCLC treatment, some patients still do not respond. NCAPG, also known as non-SMC condensin I complex subunit G, was positively associated with proliferation and migration in several tumor types.

Methods

We used transcriptional sequencing and TCGA database analysis to identify NCAPG as a new therapeutic target for NSCLC. The oncogenic roles of NCAPG in NSCLC tumor growth and metastasis were detected in vitro and in vivo. Ncapg^+/+ or Ncapg^+/- mice with urethane treatment were analyzed for oncogenesis of NSCLC.

Results

We investigated NCAPG as a new oncogenic driver which promoted NSCLC tumorigen

SUBMITTER: Sun H 

PROVIDER: S-EPMC8855584 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature