Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways.

ABSTRACT:

Background

Activins and bone morphogenetic proteins (BMPs) play critical, sometimes opposing roles, in multiple physiological and pathological processes and diseases. They signal to distinct Smad branches; activins signal mainly to Smad2/3, while BMPs activate mainly Smad1/5/8. This gives rise to the possibility that competition between the different type I receptors through which activin and BMP signal for common type II receptors can provide a mechanism for fine-tuning the cellular response to activin/BMP stimuli. Among the transforming growth factor-β superfamily type II receptors, ACVR2A/B are highly promiscuous, due to their ability to interact with different type I receptors (e.g., ALK4 vs. ALK2/3/6) and with their respective ligands [activin A (ActA) vs. BMP9/2]. However, st

SUBMITTER: Szilagyi SS 

PROVIDER: S-EPMC8855587 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature