The glucose lowering effects of CL 316,243 dissipate with repeated use and are rescued bycilostamide.

ABSTRACT: Repeated activation of the beta 3 adrenergic receptor (β3AR) with the agonist CL 316,243 (CL) results in remodeling of white adipose tissue (WAT) characterized by increased mitochondrial enzymes and expression of uncoupling protein 1 (UCP1). β3AR activation also has profound acute metabolic effects including rapidly decreasing blood glucose, secondary to fatty acid-induced increases in insulin, and increasing energy expenditure. The acute (single dose) effects of β3AR activation have largely been examined in treatment naive animals and under room temperature housing conditions. The current study examined if repeated CL treatment would lead to an attenuation of acute metabolic effects of CL treatment under thermoneutral housing conditions and if this could be rescued with cilostamide, a pho

SUBMITTER: Medak KD 

PROVIDER: S-EPMC8855634 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature