Anti-hypertensive use for non-severe gestational hypertension in Botswana: A case-control study.

ABSTRACT:

Objective

The fetal risks and benefits of antihypertensives to treat gestational hypertension in pregnancy are understudied, particularly in low- and middle-income countries.

Methods

We performed a nested case-control study within a retrospective cohort of obstetrical patients in Botswana from 2014 to 2019. We included women carrying singletons who developed new onset non-severe hypertension (140-159 mm Hg systolic or 90-109 mm Hg diastolic blood pressure) after 20 weeks of pregnancy. Cases were defined as women with either small-for-gestational-age (SGA) infants or stillbirth, analyzed separately; controls were otherwise similar women without the adverse outcome in each analysis.

Results

We identified 1932 cases of SGA (7925 controls) and 316 cases of stillbirth (961

SUBMITTER: Johnson KM 

PROVIDER: S-EPMC8855659 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature