A systematic review of the impacts of oral tetracycline class antibiotics on antimicrobial resistance in normal human flora.

ABSTRACT:

Objectives

There is interest in doxycycline as prophylaxis against sexually transmitted infections (STIs), but concern about antimicrobial resistance (AMR). We conducted a systematic review (CRD42021273301) of the impact of oral tetracycline-class antibiotics on AMR in normal flora.

Methods

We searched MEDLINE, EMBASE, the Cochrane Library (1940-2021) and conference proceedings (2014-21) for randomized controlled trials in adults comparing daily oral tetracycline-class antibiotics to non-tetracycline controls. The primary outcome was AMR to tetracyclines; secondary outcomes included resistance to non-tetracyclines. Data were inappropriate for meta-analysis, so we analysed findings descriptively.

Results

Our search yielded 6265 abstracts of which 7 articles fulfilled i

SUBMITTER: Truong R 

PROVIDER: S-EPMC8855662 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature