Multi-resolution simulation of DNA transport through large synthetic nanostructures.

ABSTRACT: Modeling and simulation has become an invaluable partner in development of nanopore sensing systems. The key advantage of the nanopore sensing method - the ability to rapidly detect individual biomolecules as a transient reduction of the ionic current flowing through the nanopore - is also its key deficiency, as the current signal itself rarely provides direct information about the chemical structure of the biomolecule. Complementing experimental calibration of the nanopore sensor readout, coarse-grained and all-atom molecular dynamics simulations have been used extensively to characterize the nanopore translocation process and to connect the microscopic events taking place inside the nanopore to the experimentally measured ionic current blockades. Traditional coarse-grained simulations, h

SUBMITTER: Choudhary A 

PROVIDER: S-EPMC8855663 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature