Development and evaluation of a high resolution 0.5mm isotropic T1-weighted template of the older adult brain.

ABSTRACT: Investigating the structure of the older adult brain at high spatial resolution is of high significance, and a dedicated older adult structural brain template with sub-millimeter resolution is currently lacking. Therefore, the purpose of this work was twofold: (A) to develop a 0.5mm isotropic resolution standardized T1-weighted template of the older adult brain by applying principles of super resolution to high quality MRI data from 222 older adults (65-95 years of age), and (B) to systematically compare the new template to other standardized and study-specific templates in terms of image quality and performance when used as a reference for alignment of older adult data. The new template exhibited higher spatial resolution and improved visualization of fine structural details of the older

SUBMITTER: Niaz MR 

PROVIDER: S-EPMC8855670 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature