Wei2GO: weighted sequence similarity-based protein function prediction.

ABSTRACT:

Background

Protein function prediction is an important part of bioinformatics and genomics studies. There are many different predictors available, however most of these are in the form of web-servers instead of open-source locally installable versions. Such local versions are necessary to perform large scale genomics studies due to the presence of limitations imposed by web servers such as queues, prediction speed, and updatability of databases.

Methods

This paper describes Wei2GO: a weighted sequence similarity and python-based open-source protein function prediction software. It uses DIAMOND and HMMScan sequence alignment searches against the UniProtKB and Pfam databases respectively, transfers Gene Ontology terms from the reference protein to the query protein, and uses a

SUBMITTER: Reijnders MJMF 

PROVIDER: S-EPMC8855713 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature