Human inhibitory leukocyte Ig-like receptors: from immunotolerance to immunotherapy.

ABSTRACT: In recent decades, immunotherapeutic strategies have been used to treat a wide range of pathologies, many of which were previously incurable, such as cancer and autoimmune disorders. Despite this unprecedented success, a considerable number of patients fail to respond to currently approved immunotherapies or develop resistance over time. Therefore, there is an urgent need to develop the next generation of immune-targeted therapies. Various members of the Ig superfamily play essential roles in regulating leukocyte functions. One such group, the leukocyte Ig-like receptors (LILRs), have been implicated in both innate and adaptive immune regulation. Human inhibitory LILRs (LILRBs) are primarily expressed on leukocytes and mediate their signaling through multiple cytoplasmic immunoreceptor tyr

SUBMITTER: De Louche CD 

PROVIDER: S-EPMC8855791 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature