Aspiration-assisted freeform bioprinting of mesenchymal stem cell spheroids within alginate microgels.

ABSTRACT: Aspiration-assisted freeform bioprinting (AAfB) has emerged as a promising technique for precise placement of tissue spheroids in three-dimensional (3D) space enabling tissue fabrication. To achieve success in embedded bioprinting using AAfB, an ideal support bath should possess shear-thinning behavior and yield-stress to facilitate tight fusion and assembly of bioprinted spheroids forming tissues. Several studies have demonstrated support baths for embedded bioprinting in the past few years, yet a majority of these materials poses challenges due to their low biocompatibility, opaqueness, complex and prolonged preparation procedures, and limited spheroid fusion efficacy. In this study, to circumvent the aforementioned limitations, we present the feasibility of AAfB of human mesenchymal ste

SUBMITTER: Kim MH 

PROVIDER: S-EPMC8855887 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature