Mixed Effect Modeling of Dose and Linear Energy Transfer Correlations With Brain Image Changes After Intensity Modulated Proton Therapy for Skull Base Head and Neck Cancer.

ABSTRACT:

Purpose

Intensity modulated proton therapy (IMPT) could yield high linear energy transfer (LET) in critical structures and increased biological effect. For head and neck cancers at the skull base this could potentially result in radiation-associated brain image change (RAIC). The purpose of the current study was to investigate voxel-wise dose and LET correlations with RAIC after IMPT.

Methods and materials

For 15 patients with RAIC after IMPT, contrast enhancement observed on T1-weighted magnetic resonance imaging was contoured and coregistered to the planning computed tomography. Monte Carlo calculated dose and dose-averaged LET (LET_d) distributions were extracted at voxel level and associations with RAIC were modelled using uni- and multivariate mixed effect log

SUBMITTER: Engeseth GM 

PROVIDER: S-EPMC8855940 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature