Pathophysiologic Signature of Impending ICU Hypoglycemia in Bedside Monitoring and Electronic Health Record Data: Model Development and External Validation.

ABSTRACT:

Objectives

We tested the hypothesis that routine monitoring data could describe a detailed and distinct pathophysiologic phenotype of impending hypoglycemia in adult ICU patients.

Design

Retrospective analysis leading to model development and validation.

Setting

All ICU admissions wherein patients received insulin therapy during a 4-year period at the University of Virginia Medical Center. Each ICU was equipped with continuous physiologic monitoring systems whose signals were archived in an electronic data warehouse along with the entire medical record.

Patients

Eleven thousand eight hundred forty-seven ICU patient admissions.

Interventions

The primary outcome was hypoglycemia, defined as any episode of blood glucose less than 70 mg/dL where 50% dextrose

SUBMITTER: Horton WB 

PROVIDER: S-EPMC8855943 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature