Patient-reported neurocognitive symptoms influence instrumental activities of daily living in sickle cell disease.

ABSTRACT: Individuals with sickle cell disease (SCD) experience neurocognitive decline, low medication adherence, increased unemployment, and difficulty with instrumental activities of daily living (IADL). The relationship between self-perceived cognitive difficulties and IADLs, including employment, school enrollment, independence, engagement in leisure activities, and medication adherence is unknown. We hypothesized that self-reported difficulties across neurocognitive areas would predict lower IADL skills. Adolescent and adult participants of the multi-site Sickle Cell Disease Implementation Consortium (SCDIC) (n = 2436) completed patient-reported outcome (PRO) measures of attention, executive functioning, processing speed, learning, and comprehension. Cognitive symptoms were analyzed as predicto

SUBMITTER: Longoria JN 

PROVIDER: S-EPMC8855994 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature