Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy.

ABSTRACT: Chemodynamic therapy (CDT) by triggering Fenton reaction or Fenton-like reaction to generate hazardous hydroxyl radical (•OH), is a promising strategy to selectively inhibit tumors with higher H₂O₂ levels and relatively acidic microenvironment. Current Fe-based Fenton nanocatalysts mostly depend on slowly releasing iron ions from Fe or Fe oxide-based nanoparticles, which leads to a limited rate of Fenton reaction. Herein, we employed black phosphorene nanosheets (BPNS), a biocompatible and biodegradable photothermal material, to develop iron-mineralized black phosphorene nanosheet (BPFe) by in situ deposition method for chemodynamic and photothermal combination cancer therapy. This study demonstrated that the BPFe could selectively increase cytotoxic ·OH in tum

SUBMITTER: Shi Z 

PROVIDER: S-EPMC8856058 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature