Characterization of neuroinflammatory positron emission tomography biomarkers in chronic traumatic encephalopathy.

ABSTRACT: Chronic traumatic encephalopathy is a neurological disorder associated with head trauma and is confirmed upon autopsy. PET imaging of chronic traumatic encephalopathy may provide a means to move towards ante-mortem diagnosis and therapeutic intervention following brain injuries. Characterization of the neuroinflammatory PET biomarkers, 18 kDa translocator protein and monoamine oxidase-B was conducted using [³H]PBR-28 and [³H]L-deprenyl, respectively, in post-mortem chronic traumatic encephalopathy brain tissue. [³H]PBR-28 displayed high specific binding in both chronic traumatic encephalopathy (95.40 ± 1.87%; n = 11 cases) and healthy controls (89.89 ± 8.52%, n = 3 cases). Cell-type expression of the 18 kDa translocator protein was confirmed b

SUBMITTER: Varlow C 

PROVIDER: S-EPMC8856182 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature