Quantitative modeling identifies critical cell mechanics driving bile duct lumen formation.

ABSTRACT: Biliary ducts collect bile from liver lobules, the smallest functional and anatomical units of liver, and carry it to the gallbladder. Disruptions in this process caused by defective embryonic development, or through ductal reaction in liver disease have a major impact on life quality and survival of patients. A deep understanding of the processes underlying bile duct lumen formation is crucial to identify intervention points to avoid or treat the appearance of defective bile ducts. Several hypotheses have been proposed to characterize the biophysical mechanisms driving initial bile duct lumen formation during embryogenesis. Here, guided by the quantification of morphological features and expression of genes in bile ducts from embryonic mouse liver, we sharpened these hypotheses and collec

SUBMITTER: Van Liedekerke P 

PROVIDER: S-EPMC8856558 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature