An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents.

ABSTRACT: The respiratory system maintains homeostatic levels of oxygen (O₂) and carbon dioxide (CO₂) in the body through rapid and efficient regulation of breathing frequency and depth (tidal volume). The commonly used methods of analyzing breathing data in behaving experimental animals are usually subjective, laborious, and time-consuming. To overcome these hurdles, we optimized an analysis toolkit for the unsupervised study of respiratory activities in animal subjects. Using this tool, we analyzed breathing behaviors of the common marmoset (Callithrix jacchus), a New World non-human primate model. Using whole-body plethysmography in room air as well as acute hypoxic (10% O₂) and hypercapnic (6% CO₂) conditions, we describe breathing behaviors in

SUBMITTER: Bishop M 

PROVIDER: S-EPMC8856653 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature