Cell-type-specific responses to associative learning in the primary motor cortex.

ABSTRACT: The primary motor cortex (M1) is known to be a critical site for movement initiation and motor learning. Surprisingly, it has also been shown to possess reward-related activity, presumably to facilitate reward-based learning of new movements. However, whether reward-related signals are represented among different cell types in M1, and whether their response properties change after cue-reward conditioning remains unclear. Here, we performed longitudinal in vivo two-photon Ca²⁺ imaging to monitor the activity of different neuronal cell types in M1 while mice engaged in a classical conditioning task. Our results demonstrate that most of the major neuronal cell types in M1 showed robust but differential responses to both the conditioned cue stimulus (CS) and reward, and their respon

SUBMITTER: Lee C 

PROVIDER: S-EPMC8856656 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature