Sodium nitrate supplementation improves blood pressure reactivity in patients with peripheral artery disease.

ABSTRACT:

Background & aims

Peripheral artery disease (PAD) is characterized by elevated blood pressure (BP), low nitric oxide availability (NO), and exaggerated pressor responses to sympatho-excitatory stressors. Inorganic nitrate reduces peripheral BP in healthy and chronically diseased populations. The objective of this study was to investigate the effects of eight-weeks of sodium nitrate (NaNO₃) supplementation on indices of BP in PAD patients.

Methods

21 patients with PAD were recruited to participate in this study, undergoing 8-weeks of NaNO₃ (n = 13; 73 ± 9 years) or placebo (n = 8; 69 ± 10 years) supplementation. BP responsiveness to a cold pressor test (CPT) were examined prior to and following the supplementation period. The systolic BP response (change

SUBMITTER: Hughes WE 

PROVIDER: S-EPMC8857030 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature