Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress.

ABSTRACT: Evaluating and coping with stressful social events as they unfold is a critical strategy in overcoming them without long-lasting detrimental effects. Individuals display a wide range of responses to stress, which can manifest in a variety of outcomes for the brain as well as subsequent behavior. Chronic Social Defeat Stress (CSDS) in mice has been widely used to model individual variation following a social stressor. Following a course of repeated intermittent psychological and physical stress, mice diverge into separate populations of social reactivity: resilient (socially interactive) and susceptible (socially avoidant) animals. A rich body of work reveals distinct neurobiological and behavioral consequences of this experience that map onto the resilient and susceptible groups. However,

SUBMITTER: Murra D 

PROVIDER: S-EPMC8857076 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature