A Two-Dimensional Model of Potassium Signaling and Oscillatory Growth in a Biofilm.

ABSTRACT: Biofilms are complex communities of bacteria that exhibit a variety of collective behaviors. These behaviors improve their ability to survive in many different environments. One of these collective behaviors seen in Bacillus subtilis is the ability for starving cells to stop the growth of other cells using potassium signaling and voltage changes. This signaling produces an oscillatory growth pattern so that during periods of low growth the nutrients diffuse deeper into the biofilm and reach the nutrient-starved, interior regions of the biomass. In this paper, we develop a mathematical model to describe this oscillatory behavior, and we use this model to develop a two-dimensional simulation that reproduces many of the important features seen in the experimental data. This simulation allows

SUBMITTER: Ford N 

PROVIDER: S-EPMC8857140 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature