A network pharmacology-based approach to explore mechanism of action of medicinal herbs for alopecia treatment.

ABSTRACT: Hair loss is one of the most common skin problems experienced by more than half of the world's population. In East Asia, medicinal herbs have been used widely in clinical practice to treat hair loss. Recent studies, including systematic literature reviews, indicate that medicinal herbs may demonstrate potential effects for hair loss treatment. In a previous study, we identified medical herbs used frequently for alopecia treatment. Herein, we explored the potential novel therapeutic mechanisms of 20 vital medicinal herbs for alopecia treatment that could distinguish them from known mechanisms of conventional drugs using network pharmacology analysis methods. We determined the herb-ingredient-target protein networks and ingredient-associated protein (gene)-associated pathway networks and cal

SUBMITTER: Leem J 

PROVIDER: S-EPMC8857194 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature