Curation, inference, and assessment of a globally reconstructed gene regulatory network for Streptomyces coelicolor.

ABSTRACT: Streptomyces coelicolor A3(2) is a model microorganism for the study of Streptomycetes, antibiotic production, and secondary metabolism in general. Even though S. coelicolor has an outstanding variety of regulators among bacteria, little effort to globally study its transcription has been made. We manually curated 29 years of literature and databases to assemble a meta-curated experimentally-validated gene regulatory network (GRN) with 5386 genes and 9707 regulatory interactions (~ 41% of the total expected interactions). This provides the most extensive and up-to-date reconstruction available for the regulatory circuitry of this organism. Only ~ 6% (534/9707) are supported by experiments confirming the binding of the transcription factor to the upstream region of the target gene, the so-c

SUBMITTER: Zorro-Aranda A 

PROVIDER: S-EPMC8857197 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature