Optical imaging spectroscopy for rapid, primary screening of SARS-CoV-2: a proof of concept.

ABSTRACT: Effective testing is essential to control the coronavirus disease 2019 (COVID-19) transmission. Here we report a-proof-of-concept study on hyperspectral image analysis in the visible and near-infrared range for primary screening at the point-of-care of SARS-CoV-2. We apply spectral feature descriptors, partial least square-discriminant analysis, and artificial intelligence to extract information from optical diffuse reflectance measurements from 5 µL fluid samples at pixel, droplet, and patient levels. We discern preparations of engineered lentiviral particles pseudotyped with the spike protein of the SARS-CoV-2 from those with the G protein of the vesicular stomatitis virus in saline solution and artificial saliva. We report a quantitative analysis of 72 samples of nasopharyngeal exudate

SUBMITTER: Gomez-Gonzalez E 

PROVIDER: S-EPMC8857323 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature