Edema in childhood nephrotic syndrome: possible genes-hormones interplay.

ABSTRACT:

Background

The role of atrial natriuretic peptide (ANP) in edema formation in idiopathic nephrotic syndrome (INS) was studied before with conflicting results reported; however, the possible contribution of genes regulating ANP expression and receptors was never explored.

Methods

One hundred children (60 with active INS and 40 in remission) were studied for plasma atrial natriuretic peptide (ANP), urinary sodium, ANP gene A2843G and ScaI polymorphisms, and natriuretic peptide receptor clearance C (-55) A polymorphism. For comparative purposes, 20 healthy controls were studied for ANP levels.

Results

ANP was higher in active compared to remission patients (p<0.001). ANP in the healthy control group was significantly lower than the ANP level of active INS (during edema)

SUBMITTER: El-Halaby H 

PROVIDER: S-EPMC8857332 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature