Migraine and Ischemic Stroke: A Mendelian Randomization Study.

ABSTRACT:

Introduction

Previous epidemiological studies have found an increased risk for ischemic stroke in patients with migraine; however, the evidence for a causal relationship between migraine and ischemic stroke is scarce. This study aims to explore the potential causal relationship between migraine and ischemic stroke and its subtypes [including large artery stroke (LAS), small vessel stroke (SVS), and cardioembolic stroke (CES)].

Methods

We used data on genetic variants associated with migraine identified from a genome-wide association study (GWAS) meta-analysis among 889,018 European ancestries. Summary data for ischemic stroke and its subtypes were obtained from the MEGASTROKE consortium including up to 438,847 participants. We performed two-sample Mendelian randomization (MR

SUBMITTER: Shu MJ 

PROVIDER: S-EPMC8857343 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature